Reaching Cinque Terre is not difficult. It is easy to reach Cinque Terre by car or by train, because Cinque Terre are close to all main italian cities (3h from Milan; 2h and 30 min from Florence; 6h from Rome or Venice),. You can reach every town by car, but it is very important to know that having a car in Cinque Terre can be a problem, few parkings and very difficult drives.
The train is the best mean of transport to visit Cinque Terre.
Closest airports are: Pisa (link) and Genova (link) only 1h and 30 minutes far by car or by train. Milano Malpensa (link) is at almost 4h. far from Cinque Terre.
Average length of travel from major italian cities